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Dodging the Central Dogma of Molecular Biology

Discover how some peptides are synthesized without the genetic code by a unique enzyme called NRP synthetase, challenging the Central Dogma. Learn about non-ribosomal peptides and their vital roles as antibiotics, anti-tumor agents, and cell communicators.

Hopefully, you’re perplexed, because the Central Dogma of Molecular Biology implies that all peptides must be encoded by the genome. Nobel laureate Edward Tatum was just as confused, and in 1963, he devised an ingenious experiment.

Protein translation

Protein translation is carried out by a molecular ...