Open Problem: Finding Replication Origins in Yeast
Discover the complexities of finding replication origins in yeast, particularly Saccharomyces cerevisiae. Learn about ARS Consensus Sequences and the challenges bioinformaticians face in predicting origins, including variable patterns and loosely defined binding sites. Understand why this remains an open problem and consider how algorithmic solutions might improve prediction accuracy.
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Replication origins in bacteria vs. yeast
If you think that finding replication origins in bacteria is a complex problem, wait until you analyze replication origins in more complex organisms like yeast or humans, which have hundreds of replication origins. Among various yeast species, the yeast Saccharomyces cerevisiae has the best characterized replication origins. It has approximately 400 different oris, many of which may be used during the replication of any single yeast cell.
ARS Consensus Sequence
Having a large number of ...