Open Problem: Multiple Replication Origins in a Bacterial Genome
Explore the unresolved question of multiple replication origins in bacterial genomes, examining unusual skew patterns and genetic rearrangements. Learn how bioinformatics algorithms can help detect and understand these replication sites in bacteria like Wigglesworthia glossinidia.
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Biologists long believed that each bacterial chromosome has only one ori. Wang et al., 2011 genetically modified E. coli by inserting a synthetic ori a million nucleotides away from the bacterium’s known ori. To their surprise, E. coli continued business as usual, starting replication at both locations!
Existence of bacteria having multiple oris
Following the publication of this paper, the search for naturally occurring bacteria with multiple oris immediately started. In 2012, Xia raised ...