The Changing Faces of Sequence Alignment: Overlap Alignment
Explore overlap alignment methods to compare biological sequences by finding the best global alignment between suffixes and prefixes. Understand how this approach helps handle error-prone reads and improves genome assembly through maximizing alignment scores.
We'll cover the following...
We'll cover the following...
Maximizing global alignment score
Earlier, we discussed how to use overlapping reads to assemble a genome, a problem that was complicated by errors in reads. Aligning the ends of the hypothetical reads shown below offers a way to find overlaps between error-prone reads.
An overlap alignment of strings = … ...