The Skew Diagram
Explore the concept of the skew diagram, which tracks the difference in guanine and cytosine counts along a genome to pinpoint DNA replication origins. Learn how this algorithmic approach reveals where replication begins by identifying shifts in nucleotide patterns, especially in circular genomes like E. coli.
We'll cover the following...
We'll cover the following...
Let’s see if we can take advantage of these peculiar statistics caused by deamination to locate ori even more accurately than the approach that we illustrated in the figure in the Peculiar Statistics of the Forward and Reverse Half-Strands lesson. As the table from Deamination illustrates, the difference between the total amount of guanine and the total amount of cytosine is negative on the reverse half-strand ( ...